Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | MMP12 | P39900 | 1/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL773711 | 0.99 | PRKCA (0.60) | PRKCAMMP12NR1I2SCN9AKMO | |
| SCHEMBL12429493 | 0.91 | PRKCA (0.52) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| Hydrochloric Acid SCHEMBL772829 | 0.91 | PRKCA (0.52) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| SCHEMBL773242 | 0.90 | PRKCA (0.55) | PRKCAMMP12NR1I2SCN9AKMO | |
| SCHEMBL772658 | 0.88 | PRKCA (0.51) | PRKCAMMP12NR1I2SCN9AKMO | |
| SCHEMBL772119 | 0.87 | PRKCA (0.53) | PRKCAMMP12NR1I2SCN9AKMO | |
| SCHEMBL12429463 | 0.86 | PRKCA (0.56) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| Hydrochloric Acid SCHEMBL773108 | 0.86 | PRKCA (0.56) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| SCHEMBL771459 | 0.85 | PRKCA (0.51) | PRKCAMMP12NR1I2SCN9AKMO | |
| SCHEMBL771869 | 0.85 | PRKCA (0.56) | PRKCAMMP12NR1I2SCN9AKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| EP-2206715-A1 | Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor | Japan Tobacco, Inc. (JP) | 2010-07-14 | — | — | EP | disclosed |
| EP-1719773-B1 | FUSED HETEROTETRACYCLIC COMPOUNDS AND USE TEHREOF AS HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1719773-A1 | FUSED HETEROTETRACYCLIC COMPOUNDS AND USE TEHREOF AS HCV POLYMERASE INHIBITOR | Japan Tobacco, Inc. (JP) | 2006-11-08 | — | — | EP | disclosed |