Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3782101 | 1.00 | GBA1 (0.47) | GBA1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL3806943 | 0.90 | GBA1 (0.52) | GBA1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL3806946 | 0.90 | GBA1 (0.52) | GBA1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL3706548 | 0.81 | PDE5A (0.47) | GBA1ADORA1ADORA2AADORA3ADORA2B | |
| SCHEMBL3708230 | 0.81 | PDE5A (0.61) | GBA1MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3706663 | 0.80 | CCNE2 (0.48) | GBA1MEN1KMT2AALDH1A1ADORA1 | |
| SCHEMBL30772425 | 0.80 | PDE5A (0.41) | GBA1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL2803755 | 0.80 | PDE5A (0.41) | GBA1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL13283709 | 0.75 | GBA1 (0.46) | GBA1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL3809901 | 0.69 | PDE5A (0.49) | GBA1MEN1KMT2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010081881-A1 | AURORA KINASE INHIBITORS COMPOUNDS. | UNIVERSITÄT LEIPZIG (DE) | 2010-07-22 | — | — | WO | claimed |
| WO-2010081881-A1 | AURORA KINASE INHIBITORS COMPOUNDS. | UNIVERSITÄT LEIPZIG (DE) | 2010-07-22 | — | — | WO | disclosed |