Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 17/20 | 0.47 |
| ▸ | AKT2 | P31751 | 12/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.38 |
| ▸ | FECH | P22830 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224643 | 0.84 | AKT1 (0.47) | AKT1AKT2AKT3FECH | |
| SCHEMBL1352350 | 0.83 | AKT1 (0.69) | AKT1AKT2AKT3FECH | |
| Hydrochloric Acid SCHEMBL1351578 | 0.82 | AKT1 (0.67) | AKT1AKT2AKT3FECH | |
| SCHEMBL3704335 | 0.81 | AKT1 (0.46) | AKT1AKT2AKT3FECH | |
| SCHEMBL1350141 | 0.80 | AKT1 (0.41) | AKT1AKT2AKT3FECHPSMB5 | |
| SCHEMBL29533424 | 0.79 | KDM4E (0.50) | AKT1AKT2PSMB5KDM4EL3MBTL1 | |
| SCHEMBL22919342 | 0.79 | KDM4E (0.50) | AKT1AKT2PSMB5KDM4EL3MBTL1 | |
| SCHEMBL12133540 | 0.79 | AKT1 (0.51) | AKT1AKT2 | |
| SCHEMBL3709058 | 0.78 | AKT1 (0.53) | AKT1AKT2AKT3FECHPSMB5 | |
| SCHEMBL15135637 | 0.78 | AKT1 (0.46) | AKT1AKT2AKT3FECHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |
| WO-2009148887-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2009-12-10 | — | — | WO | disclosed |