Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.47 |
| ▸ | AKT2 | P31751 | 10/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.38 |
| ▸ | FECH | P22830 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3783328 | 0.84 | AKT1 (0.47) | AKT1AKT2AKT3FECH | |
| SCHEMBL1538608 | 0.81 | AKT1 (0.42) | AKT1AKT2AKT3FECH | |
| SCHEMBL1607881 | 0.80 | AKT1 (0.46) | AKT1AKT2AKT3FECH | |
| SCHEMBL3836976 | 0.80 | AKT1 (0.46) | AKT1AKT2AKT3FECH | |
| SCHEMBL12710396 | 0.80 | AKT1 (0.49) | AKT1AKT2 | |
| SCHEMBL12710381 | 0.79 | AKT1 (0.59) | AKT1AKT2 | |
| SCHEMBL1539149 | 0.79 | AKT1 (0.44) | AKT1AKT2AKT3FECH | |
| SCHEMBL4223010 | 0.78 | AKT1 (0.41) | AKT1AKT2 | |
| SCHEMBL3709058 | 0.76 | AKT1 (0.53) | AKT1AKT2AKT3FECH | |
| SCHEMBL4224640 | 0.76 | AKT1 (0.35) | AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009148887-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2009-12-10 | — | — | WO | disclosed |