Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.55 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 10/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30491750 | 0.84 | NR3C1 (0.52) | CYP11B2CYP11B1MGAMGAASI | |
| SCHEMBL20603936 | 0.78 | MGAM (0.49) | CYP11B2CYP11B1MGAMGAASI | |
| SCHEMBL29496843 | 0.78 | NPC1 (0.61) | CYP11B2CYP11B1MGAMGAASI | |
| SCHEMBL30270004 | 0.77 | KDM4E (0.56) | CYP11B2CYP11B1MGAMGAASI | |
| SCHEMBL729956 | 0.77 | KDM4E (0.56) | CYP11B2CYP11B1MGAMGAASI | |
| Hydrochloric Acid SCHEMBL5551165 | 0.77 | MKNK1 (0.42) | CYP11B2CYP11B1NR3C1PGR | |
| Hydrochloric Acid SCHEMBL3379409 | 0.76 | KDM4E (0.55) | CYP11B2CYP11B1MGAMGAASI | |
| SCHEMBL1880811 | 0.75 | NR3C1 (0.55) | CYP11B2CYP11B1MGAMGAASI | |
| SCHEMBL19780904 | 0.75 | NPC1 (0.61) | CYP11B2CYP11B1MGAMGAASI | |
| SCHEMBL29399064 | 0.75 | NR3C1 (0.55) | CYP11B2CYP11B1MGAMGAASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855222-B2 | Methods for treating a disease in which Rho kinase is involved | UBE INDUSTRIES, LTD. (JP) | 2010-12-21 | — | — | US | claimed |