Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 6/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MAP4K3 | Q8IVH8 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3793473 | 0.91 | ALK (0.38) | FEN1ALOX5APLRRK2MAPK1ALK | |
| Hydrochloric Acid SCHEMBL3787624 | 0.91 | CCNT1 (0.38) | FEN1ALOX5APLRRK2CCNT1CDK9 | |
| SCHEMBL3785164 | 0.88 | ALOX5AP (0.34) | FEN1ALOX5APLRRK2ALKCCNT1 | |
| Hydrochloric Acid SCHEMBL3789023 | 0.88 | ALK (0.36) | FEN1ALOX5APLRRK2ALKCCNT1 | |
| SCHEMBL3786748 | 0.88 | LRRK2 (0.35) | FEN1ALOX5APLRRK2ALKMAP3K7 | |
| Hydrochloric Acid SCHEMBL3786913 | 0.88 | MET (0.33) | FEN1ALOX5APLRRK2ALKCCNT1 | |
| Hydrochloric Acid SCHEMBL3785350 | 0.87 | ALK (0.35) | FEN1ALOX5APLRRK2ALKCCNT1 | |
| Hydrochloric Acid SCHEMBL3785978 | 0.87 | ALK (0.37) | FEN1ALOX5APLRRK2ALKCCNT1 | |
| Hydrochloric Acid SCHEMBL3786119 | 0.86 | ALK (0.33) | FEN1ALOX5APLRRK2ALKCCNT1 | |
| Hydrochloric Acid SCHEMBL3789781 | 0.85 | ALK (0.34) | FEN1ALOX5APLRRK2ALKCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |