SCHEMBL378478

SCHEMBL378478

N#Cc1ccc(Oc2ccccc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.63
TSHR P16473 2/20 0.59
MAOB P27338 2/20 0.59
LTA4H P09960 5/20 0.57
PARP15 Q460N3 1/20 0.55
PARP10 Q53GL7 1/20 0.55
PARP2 Q9UGN5 1/20 0.55
KDM4E B2RXH2 2/20 0.53
LMNA P02545 2/20 0.53
MEN1 O00255 1/20 0.53
POLB P06746 1/20 0.53
MAPT P10636 1/20 0.53
PKM P14618 1/20 0.53
MAPK1 P28482 1/20 0.53
RAB9A P51151 1/20 0.53
KMT2A Q03164 1/20 0.53
IL18 Q14116 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.51
PGR P06401 2/20 0.51
NR3C1 P04150 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11592335 0.94 CYP19A1 (0.58) CYP19A1TSHRMAOBLTA4HPARP15
Diphenylether SCHEMBL4188767 0.93 TSHR (0.70) CYP19A1TSHRMAOBLTA4HPARP15
SCHEMBL7041250 0.90 PARP15 (0.63) CYP19A1TSHRMAOBPARP15PARP10
SCHEMBL8852392 0.90 PARP15 (0.63) CYP19A1TSHRMAOBPARP15PARP10
SCHEMBL24476964 0.89 KDM4E (0.55) CYP19A1TSHRMAOBLTA4HPARP15
Thianthrene SCHEMBL31297759 0.88 CYP19A1 (0.53) CYP19A1TSHRMAOBLTA4HPARP15
SCHEMBL10927383 0.86 CYP19A1 (0.59) CYP19A1MAOBPARP15PARP10PARP2
SCHEMBL24124458 0.86 SMN1; SMN2 (0.65) CYP19A1TSHRMAOBPARP15PARP10
SCHEMBL31297758 0.85 CYP19A1 (0.58) CYP19A1TSHRMAOBLTA4HPARP15
SCHEMBL20240289 0.84 MAOB (0.62) CYP19A1TSHRMAOBLTA4HPARP15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3877447-B1 COMPOSITION OF PHTHALONITRILE RESIN MATRIX FOR POLYMER COMPOSITE MATERIALS, METHOD FOR FABRICATION THEREOF, METHOD FOR MANUFACTURING OF POLYMER COMPOSITE MATERIAL, AND MATERIAL OBTAINED BY THIS METHOD JOINT STOCK COMPANY (RU) 2024-07-17 EP claimed
CN-113024530-B Isatin-1, 2, 4-oxadiazole compound and preparation method and application thereof 合肥工业大学 2023-07-18 CN claimed
CN-113024530-A Isatin-1, 2, 4-oxadiazole compound and preparation method and application thereof 合肥工业大学 2021-06-25 CN claimed
US-20250242338-A1 IRON PHOSPHIDE NANOPARTICLES, AND COMPOSITE BODY AND REDUCTION CATALYST EACH CONTAINING SAME OSAKA UNIVERSITY (JP) 2025-07-31 US disclosed
CN-119504592-A Synthesis method of 3-amino-5- (4-phenoxyphenyl) -4-cyano-1H-pyrazole 深圳智微通科技有限公司 2025-02-25 CN disclosed
EP-4509462-A1 IRON PHOSPHIDE NANOPARTICLES, AND COMPOSITE BODY AND REDUCTION CATALYST EACH CONTAINING SAME OSAKA UNIVERSITY (JP) 2025-02-19 EP disclosed
CN-119219454-A Method for preparing aromatic nitrile compound by photoinitiating nitroarene denitration cyanation 武汉光化学技术研究院 2024-12-31 CN disclosed
CN-119053551-A Nano iron phosphide particles, composite containing nano iron phosphide particles and reduction catalyst 国立大学法人大阪大学 2024-11-29 CN disclosed
CN-119039219-A Preparation method and application of (hetero) aryl trifluoromethyl tellurium ether compound 武汉理工大学 2024-11-29 CN disclosed
CN-115369432-B Method for preparing nitrile by electrocatalytic coupling of primary alcohol and ammonia substance 大连理工大学 2024-08-20 CN disclosed
CN-118359503-A Synthesis method of copper-catalyzed diaryl ether promoted by visible light 新疆大学 2024-07-19 CN disclosed
US-4394327-A THIOESTERS CIBA-GEIGY CORPORATION (US) 1983-07-19 US disclosed
US-4304936-A Herbicidal 3-(trifluro-methyl-halophenoxy)-α-phenoxyalkanecarboxylic acid amides CIBA-GEIGY CORPORATION (US) 1981-12-08 US disclosed
US-4287125-A Preparation of benzenoid ethers and thioethers RHONE-POULENC INDUSTRIES (FR) 1981-09-01 US disclosed
US-4247682-A DOUBLE ENDCAPPING BY AN ELECTROPHILIC AND A NUCLEOPHILIC END GROUP OF A POLYMER PREPARED BY AN ELECTRONEGITIVELY SUBSTITUTED AROMATIC ACID HALIDE OR SULFONYL HALIDE; MOLECULAR WEIGHT CONTROL; HEAT RESISTANCE RAYCHEM CORPORATION (US) 1981-01-27 US disclosed
EP-0022387-A1 Process for the preparation of benzene derivatives by the reaction of an activated halobenzene with an organic compound containing an oxygen or sulphur anion RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1981-01-14 EP disclosed
US-4227914-A Herbicidal phenoxyalkyloxazolines CIBA-GEIGY CORPORATION (US) 1980-10-14 US disclosed
EP-0008532-A1 Synthesis of amines SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1980-03-05 EP disclosed
US-4172782-A ORGANIC QUATERNARY AMMONIUM SALT USED IN ALKULATION OF BENZYLNITRILE WITH AN ORGANIC HALIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1979-10-30 US disclosed
US-4019996-A CONTAINING MONOCYANO-PHENOXYBENZENE, -DIPHENYL OR -TERPHENYL IN A LIQUID RHONE-POULENC INDUSTRIES (FR) 1977-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250242338-A1 IRON PHOSPHIDE NANOPARTICLES, AND COMPOSITE BODY AND REDUCTION CATALYST EACH CONTAINING SAME FECH, PI4K2A, PHOSPHO1 CYP19A1 1247/4885TSHR 2770/4885MAOB 3002/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.