Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22919342 | 0.87 | KDM4E (0.50) | KDM4EL3MBTL1GAALMNAAKT1 | |
| SCHEMBL29533424 | 0.87 | KDM4E (0.50) | KDM4EL3MBTL1GAALMNAAKT1 | |
| SCHEMBL4223010 | 0.81 | AKT1 (0.41) | KDM4EL3MBTL1GAALMNAAKT1 | |
| SCHEMBL3784838 | 0.81 | KDM4E (0.39) | KDM4EL3MBTL1GAALMNAAKT1 | |
| SCHEMBL3781515 | 0.80 | AKT1 (0.42) | KDM4EL3MBTL1GAALMNAAKT1 | |
| SCHEMBL1352350 | 0.79 | AKT1 (0.69) | AKT1AKT2 | |
| Hydrochloric Acid SCHEMBL1351578 | 0.78 | AKT1 (0.67) | AKT1AKT2 | |
| SCHEMBL12710373 | 0.78 | AKT1 (0.63) | KDM4EL3MBTL1GAALMNAAKT1 | |
| SCHEMBL3785540 | 0.77 | AKT1 (0.39) | KDM4EL3MBTL1GAALMNAAKT1 | |
| SCHEMBL3783328 | 0.77 | AKT1 (0.47) | KDM4EL3MBTL1GAALMNAAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2299825-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2013-07-31 | — | — | EP | disclosed |
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |