Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 3/20 | 0.46 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.37 |
| ▸ | MAP4K3 | Q8IVH8 | 3/20 | 0.36 |
| ▸ | GRK2 | P25098 | 2/20 | 0.35 |
| ▸ | GRK5 | P34947 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791132 | 0.90 | ILK (0.41) | ILKMAP4K3GRK2GRK5DYRK1A | |
| SCHEMBL3781299 | 0.88 | DYRK1A (0.38) | ILKMAP4K3GRK2GRK5DYRK1A | |
| SCHEMBL3790558 | 0.87 | MAPT (0.43) | ILKMAP4K3GRK2GRK5DYRK1A | |
| SCHEMBL3792929 | 0.87 | NPC1 (0.47) | ILKAGPAT2MAP4K3GRK2GRK5 | |
| SCHEMBL3786015 | 0.85 | DYRK1A (0.49) | ILKGRK2GRK5DYRK1A | |
| SCHEMBL3790642 | 0.85 | APP (0.37) | ILKMAP4K3GRK2GRK5DYRK1A | |
| Hydrochloric Acid SCHEMBL3786770 | 0.85 | ILK (0.50) | ILKKCNH2MEN1POLBKMT2A | |
| SCHEMBL3791085 | 0.84 | ILK (0.44) | ILKGRK2GRK5 | |
| SCHEMBL3790471 | 0.82 | MAP4K3 (0.35) | ILKMAP4K3GRK2GRK5KCNH2 | |
| SCHEMBL3790635 | 0.82 | LRRK2 (0.37) | ILKMAP4K3GRK2GRK5PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |