Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.46 |
| ▸ | ILK | Q13418 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786015 | 0.93 | DYRK1A (0.49) | APPILKLRRK2DYRK1A | |
| SCHEMBL3792301 | 0.90 | MAPT (0.43) | APPILKLRRK2GLAGAA | |
| SCHEMBL3791085 | 0.89 | ILK (0.44) | APPILK | |
| SCHEMBL3788570 | 0.88 | APP (0.41) | APPILKLRRK2 | |
| SCHEMBL3790687 | 0.86 | APP (0.46) | APPILKLRRK2 | |
| Hydrochloric Acid SCHEMBL3786770 | 0.86 | ILK (0.50) | APPILKGAA | |
| SCHEMBL3790558 | 0.84 | MAPT (0.43) | APPILKLRRK2DYRK1AGLA | |
| SCHEMBL3791132 | 0.83 | ILK (0.41) | APPILKLRRK2DYRK1A | |
| SCHEMBL3789591 | 0.83 | LRRK2 (0.41) | ILKLRRK2 | |
| SCHEMBL3792929 | 0.82 | NPC1 (0.47) | APPILKLRRK2DYRK1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265270-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009099982-A1 | 2-AMINOPYRIDINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |