Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12133441 | 0.87 | NAMPT (0.46) | AKT1 | |
| SCHEMBL3788803 | 0.84 | KMT2A (0.44) | TP53LMNARXFP1AKT1AKT2 | |
| SCHEMBL3787154 | 0.84 | DHODH (0.46) | TP53LMNARXFP1CNR1TACR3 | |
| SCHEMBL12134712 | 0.83 | ERBB2 (0.44) | LMNARXFP1CNR1PDE10ATHRB | |
| SCHEMBL1350616 | 0.83 | CNR1 (0.41) | LMNARXFP1AKT1CNR1PDE10A | |
| SCHEMBL3788617 | 0.82 | TP53 (0.42) | TP53LMNARXFP1AKT1AKT2 | |
| SCHEMBL27755776 | 0.82 | TP53 (0.42) | TP53LMNARXFP1AKT1AKT2 | |
| SCHEMBL12803747 | 0.82 | KMT2A (0.47) | TP53LMNARXFP1CNR1TACR3 | |
| SCHEMBL3790086 | 0.82 | TP53 (0.44) | TP53LMNARXFP1AKT1AKT2 | |
| SCHEMBL3704426 | 0.82 | CNR1 (0.42) | AKT1AKT2CNR1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |