Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12803747 | 0.90 | KMT2A (0.47) | TP53LMNARXFP1THRB | |
| SCHEMBL12133448 | 0.88 | NAMPT (0.48) | AKT1HDAC1 | |
| SCHEMBL1352758 | 0.86 | SYK (0.42) | AKT1AKT2PDE10ASYKDHODH | |
| SCHEMBL3788803 | 0.85 | KMT2A (0.44) | TP53LMNARXFP1AKT1AKT2 | |
| SCHEMBL3787154 | 0.85 | DHODH (0.46) | TP53LMNARXFP1THRBDHODH | |
| Hydrochloric Acid SCHEMBL1350850 | 0.85 | SYK (0.41) | AKT1AKT2PDE10ASYKDHODH | |
| SCHEMBL3788617 | 0.83 | TP53 (0.42) | TP53LMNARXFP1AKT1AKT2 | |
| SCHEMBL27755776 | 0.83 | TP53 (0.42) | TP53LMNARXFP1AKT1AKT2 | |
| SCHEMBL12803421 | 0.82 | KLKB1 (0.48) | TP53LMNA | |
| SCHEMBL3786276 | 0.82 | EGLN1 (0.42) | TP53LMNARXFP1AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |