Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 11/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778691 | 0.89 | TLR9 (0.45) | TLR9TLR7CNR2KMT2APOLB | |
| SCHEMBL3788619 | 0.88 | HRH4 (0.45) | TLR9TLR7CNR2KMT2APOLB | |
| SCHEMBL3789179 | 0.86 | EHMT2 (0.42) | TLR9TLR7CNR2KMT2APOLB | |
| SCHEMBL3785017 | 0.86 | TLR9 (0.49) | TLR9TLR7CNR2KMT2APOLB | |
| SCHEMBL3786031 | 0.85 | CNR2 (0.42) | TLR9TLR7CNR2KMT2APOLB | |
| SCHEMBL3791449 | 0.85 | PDE10A (0.49) | CNR2KMT2APOLBKDM4EMEN1 | |
| SCHEMBL3702927 | 0.85 | TLR7 (0.45) | TLR9TLR7CNR2KMT2APOLB | |
| SCHEMBL13285966 | 0.83 | TSHR (0.46) | TLR7CNR2ALDH1A1GAAMAPT | |
| SCHEMBL3781321 | 0.83 | HTR3E (0.46) | TLR9TLR7CNR2KMT2APOLB | |
| SCHEMBL13286132 | 0.83 | TLR9 (0.49) | TLR9TLR7CNR2KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010083645-A1 | PYRIMIDO[5,4-e][1,2,4]TRIAZINES AND USES THEREOF | SHANGHAI TARGETDRUG CO., LTD (CN) | 2010-07-29 | — | — | WO | disclosed |