Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723554 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2C19MEN1KMT2ANPSR1 | |
| SCHEMBL3789360 | 0.83 | MEN1 (0.46) | SMN1; SMN2CYP2C19OPRD1OPRK1MEN1 | |
| SCHEMBL31375608 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2CYP2C19MEN1KMT2ANPSR1 | |
| SCHEMBL28216747 | 0.80 | MEN1 (0.48) | SMN1; SMN2MEN1KMT2ANPSR1NPC1 | |
| SCHEMBL30832481 | 0.80 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2ANPSR1NPC1 | |
| SCHEMBL3393922 | 0.79 | MEN1 (0.47) | SMN1; SMN2OPRD1MEN1KMT2ANPSR1 | |
| SCHEMBL28536867 | 0.79 | MEN1 (0.47) | SMN1; SMN2OPRD1MEN1KMT2ANPSR1 | |
| SCHEMBL7606324 | 0.79 | MEN1 (0.49) | SMN1; SMN2MEN1KMT2ANPSR1NPC1 | |
| SCHEMBL31336435 | 0.79 | CYP2C19 (0.44) | SMN1; SMN2CYP2C19MEN1KMT2ANPSR1 | |
| SCHEMBL3398748 | 0.78 | MEN1 (0.46) | MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391603-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086251-A1 | AROYLAMINO - AND HETEROAROYLAMINO-SUBSTITUTED PIPERIDINES AS GLYT-1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |