Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784146 | 0.80 | HTR1A (0.45) | IRAK4IRAK1MKNK1MKNK2TMEM97 | |
| SCHEMBL3781660 | 0.79 | TMEM97 (0.55) | IRAK4IRAK1TMEM97SIGMAR1IKBKB | |
| SCHEMBL3715640 | 0.77 | DDB1 (0.53) | KDM4ESLC6A4HTR1ASLC6A2HRH1 | |
| SCHEMBL3790744 | 0.77 | HRH1 (0.48) | HRH1HTR2CHTR2B | |
| SCHEMBL3713864 | 0.76 | HRH1 (0.50) | HRH1HTR2CHTR2B | |
| SCHEMBL3716533 | 0.76 | CACNB4 (0.54) | HRH1 | |
| SCHEMBL1148343 | 0.75 | HRH1 (0.64) | HRH1HTR2CHTR2B | |
| SCHEMBL3786278 | 0.74 | HRH1 (0.53) | HRH1NMT1 | |
| SCHEMBL1148340 | 0.74 | HRH1 (0.60) | HRH1HTR2CHTR2B | |
| SCHEMBL3716534 | 0.74 | HRH1 (0.45) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |