Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 7/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | JAK3 | P52333 | 4/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28591822 | 0.79 | ADORA2A (0.36) | ADORA2APRMT5WDR77FLT3KDM4E | |
| SCHEMBL20593153 | 0.79 | TGFBR1 (0.43) | — | |
| SCHEMBL3707769 | 0.79 | CYP1A2 (0.53) | PRMT5WDR77KDM4EALDH1A1HPGD | |
| SCHEMBL5100079 | 0.79 | POLB (0.47) | PRMT5WDR77FLT3ALDH1A1 | |
| SCHEMBL1865755 | 0.79 | MAP3K14 (0.43) | ADORA2AFLT3ALDH1A1 | |
| SCHEMBL28589494 | 0.78 | ADORA2A (0.35) | ADORA2APRMT5WDR77FLT3KDM4E | |
| SCHEMBL1874458 | 0.78 | DYRK1A (0.40) | FLT3JAK2CYP11B2 | |
| SCHEMBL12097467 | 0.78 | PIK3CA (0.40) | FLT3CYP11B1CYP11B2 | |
| SCHEMBL28417731 | 0.75 | FLT3 (0.49) | ADORA2APRMT5WDR77FLT3JAK2 | |
| SCHEMBL1356277 | 0.75 | TGFBR1 (0.50) | ADORA2APRMT5WDR77FLT3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391625-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | Domain Therapeutics (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010084425-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | DOMAIN THERAPEUTICS (FR) | 2010-07-29 | — | — | WO | disclosed |
| EP-2210891-A1 | New adenosine receptor ligands and uses thereof | Domain Therapeutics (FR) | 2010-07-28 | — | — | EP | disclosed |