Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.62 |
| ▸ | KDR | P35968 | 11/20 | 0.54 |
| ▸ | SRC | P12931 | 10/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.52 |
| ▸ | PRKDC | P78527 | 8/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 9/20 | 0.49 |
| ▸ | EGFR | P00533 | 9/20 | 0.49 |
| ▸ | HCK | P08631 | 7/20 | 0.49 |
| ▸ | MTOR | P42345 | 7/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.49 |
| ▸ | ABL2 | P42684 | 2/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14575510 | 0.98 | RET (0.66) | RETKDRSRCLCKTEK | |
| SCHEMBL10068589 | 0.84 | RET (0.68) | RETKDRSRCPIK3CDPIK3CA | |
| SCHEMBL863887 | 0.84 | RET (0.52) | RETKDRSRCLCKLYN | |
| SCHEMBL864634 | 0.84 | SRC (0.53) | RETKDRSRCLCKBTK | |
| SCHEMBL864876 | 0.82 | SRC (0.54) | RETKDRSRCLCKLYN | |
| SCHEMBL19335163 | 0.79 | BTK (0.77) | KDRSRCLCKLYNBTK | |
| SCHEMBL19763807 | 0.77 | RET (1.00) | RET | |
| SCHEMBL19335162 | 0.76 | BTK (0.80) | RETKDRSRCLCKLYN | |
| SCHEMBL22364036 | 0.75 | BTK (0.79) | RETKDRSRCLCKLYN | |
| SCHEMBL19335138 | 0.75 | BTK (0.79) | RETKDRSRCLCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2009062118-A2 | MODULATION OF PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331297-A1 | MODULATION OF PROTEIN TRAFFICKING | RAB1A, COPB1, GOLT1B | RET 3063/4885KDR 4598/4885SRC 1332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.