Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3786246 | 0.99 | PDE4B (0.41) | PDE4BPDE4DMAOBHRH1LMNA | |
| SCHEMBL3468023 | 0.92 | PDE4B (0.42) | PDE4BPDE4DLMNAFYNMAPK9 | |
| SCHEMBL3798675 | 0.88 | PDE4B (0.42) | PDE4BPDE4DLMNAFYNMAPK10 | |
| SCHEMBL3467151 | 0.86 | PDE4B (0.39) | PDE4BPDE4DFYN | |
| SCHEMBL3467239 | 0.86 | PDE4B (0.41) | PDE4BPDE4DFYNMAPK10CTSA | |
| Hydrochloric Acid SCHEMBL3788941 | 0.85 | PDE4D (0.43) | PDE4BPDE4DLMNA | |
| SCHEMBL4323960 | 0.85 | PDE4B (0.41) | PDE4BPDE4DLMNAMAPK9MAPK10 | |
| SCHEMBL7914640 | 0.85 | KDR (0.45) | PDE4BPDE4DMAOBFYNCTSA | |
| SCHEMBL8067934 | 0.85 | PDE4B (0.41) | PDE4BPDE4DMAPK10CTSA | |
| SCHEMBL4325092 | 0.84 | PDE4B (0.39) | PDE4BPDE4DFYNMAPK10CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222638-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |