Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325092 | 0.91 | PDE4B (0.39) | KDREPHB4TEKPDE4BPDE4D | |
| SCHEMBL3467239 | 0.90 | PDE4B (0.41) | PDE4BPDE4DFYNNPC1MAPT | |
| SCHEMBL8067934 | 0.89 | PDE4B (0.41) | PDE4BPDE4DNPC1MAPTTSHR | |
| SCHEMBL3795717 | 0.89 | HTR1A (0.38) | KDREPHB4TEKPDE4BPDE4D | |
| SCHEMBL3467151 | 0.88 | PDE4B (0.39) | PDE4BPDE4DFYNNPC1MAPT | |
| SCHEMBL7902765 | 0.88 | PDE4B (0.39) | PDE4BPDE4DFYNHCRTR1HCRTR2 | |
| SCHEMBL8024594 | 0.88 | PDE4B (0.42) | PDE4BPDE4DFYNNPC1MAPT | |
| SCHEMBL4323960 | 0.88 | PDE4B (0.41) | PDE4BPDE4DMAPT | |
| SCHEMBL3468023 | 0.87 | PDE4B (0.42) | PDE4BPDE4DFYN | |
| SCHEMBL3798675 | 0.87 | PDE4B (0.42) | PDE4BPDE4DGRM2FYNNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |