Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 14/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788746 | 0.90 | EPHX2 (0.45) | EPHX2ROCK2ROCK1GPR139 | |
| SCHEMBL3795518 | 0.89 | EPHX2 (0.44) | EPHX2ROCK2ROCK1GPR139 | |
| SCHEMBL3794448 | 0.89 | EPHX2 (0.44) | EPHX2ROCK2ROCK1KLKB1GPR139 | |
| SCHEMBL3810011 | 0.88 | EPHX2 (0.49) | EPHX2TSHR | |
| SCHEMBL3790712 | 0.88 | EPHX2 (0.51) | EPHX2ROCK2ROCK1GPR139 | |
| SCHEMBL3788311 | 0.87 | DDR1 (0.40) | EPHX2ROCK2ROCK1 | |
| SCHEMBL3786760 | 0.86 | EPHX2 (0.48) | EPHX2ROCK2ROCK1 | |
| SCHEMBL3788832 | 0.86 | EPHX2 (0.40) | EPHX2ROCK2ROCK1GPR139 | |
| SCHEMBL3792366 | 0.85 | EPHX2 (0.49) | EPHX2ROCK2ROCK1 | |
| SCHEMBL13257860 | 0.84 | EPHX2 (0.45) | EPHX2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |