Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.35 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3798917 | 0.93 | EPHX2 (0.39) | EPHX2GPR139DDR1ROCK2ROCK1 | |
| SCHEMBL3790479 | 0.89 | GPR139 (0.41) | EPHX2GPR139DDR1ROCK2ROCK1 | |
| SCHEMBL3810168 | 0.88 | CD274 (0.42) | EPHX2DDR1 | |
| SCHEMBL3790712 | 0.87 | EPHX2 (0.51) | EPHX2GPR139DDR1ROCK2ROCK1 | |
| SCHEMBL3788290 | 0.86 | EPHX2 (0.46) | EPHX2GPR139ROCK2ROCK1 | |
| SCHEMBL3787484 | 0.85 | EPHX2 (0.39) | EPHX2GPR139ROCK2ROCK1RIPK1 | |
| SCHEMBL3786760 | 0.85 | EPHX2 (0.48) | EPHX2ROCK2ROCK1RIPK1 | |
| Hydrochloric Acid SCHEMBL3792564 | 0.84 | EPHX2 (0.39) | EPHX2GPR139ROCK2ROCK1RIPK1 | |
| SCHEMBL3788311 | 0.84 | DDR1 (0.40) | EPHX2DDR1ROCK2ROCK1RIPK1 | |
| Sulfuric Acid SCHEMBL3794696 | 0.83 | EPHX2 (0.38) | EPHX2DDR1ROCK2ROCK1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |