SCHEMBL378832

SCHEMBL378832

ClCc1ccc(Cl)nc1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.45
NPSR1 Q6W5P4 1/20 0.41
ALDH1A1 P00352 1/20 0.38
GFER P55789 1/20 0.38
CRHBP P24387 1/20 0.31
CRHR2 Q13324 1/20 0.31
TUBB4A P04350 1/20 0.31
TUBB P07437 1/20 0.31
TUBA3C P0DPH7 1/20 0.31
TUBA1B P68363 1/20 0.31
TUBA4A P68366 1/20 0.31
TUBB4B P68371 1/20 0.31
TUBB3 Q13509 1/20 0.31
TUBB2A Q13885 1/20 0.31
TUBB8 Q3ZCM7 1/20 0.31
TUBA3E Q6PEY2 1/20 0.31
TUBA1A Q71U36 1/20 0.31
TUBA1C Q9BQE3 1/20 0.31
TUBB6 Q9BUF5 1/20 0.31
TUBB2B Q9BVA1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5214006 0.98 KMT2A (0.44) KMT2ANPSR1ALDH1A1GFERCRHBP
SCHEMBL5745630 0.78 CTRC (0.39) KMT2ANPSR1TUBB4ATUBBTUBA3C
SCHEMBL29416271 0.78 KMT2A (0.35) KMT2ANPSR1ALDH1A1GFERCRHBP
SCHEMBL844810 0.78 KDM4E (0.40) KMT2AALDH1A1CRHBPCRHR2TUBB4A
SCHEMBL7083846 0.78 CD274 (0.41) KMT2ACRHBPCRHR2TUBB4ATUBB
SCHEMBL3885727 0.78 KMT2A (0.35) KMT2ANPSR1ALDH1A1GFERCRHBP
SCHEMBL30968506 0.78 KDM4E (0.40) KMT2AALDH1A1CRHBPCRHR2TUBB4A
SCHEMBL844505 0.78 KMT2A (0.31) KMT2ACRHBPCRHR2TUBB4ATUBB
SCHEMBL13066848 0.78 IDO1 (0.41) KMT2ACRHBPCRHR2TUBB4ATUBB
SCHEMBL9899335 0.76 KMT2A (0.34) KMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5475112-A Reducing a substituted trichloromethylpyridine derivative in presence of a proton donor and solvent ISHIHARA SANGYO KAISHA LTD. (JP) 1995-12-12 US claimed
US-3956340-A Process for the production of polyhalogenated nicotinic acids CIBA-GEIGY CORPORATION (US) 1976-05-11 US claimed
EP-4644373-A1 HYDRAZIDE COMPOUND AND AGRICULTURAL/HORTICULTURAL BACTERICIDAL AGENT Nippon Soda Co., Ltd. (JP) 2025-11-05 EP disclosed
WO-2025007784-A1 HETEROAROMATIC RING COMPOUND, PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2025-01-09 WO disclosed
WO-2024143336-A1 HYDRAZIDE COMPOUND AND AGRICULTURAL/HORTICULTURAL BACTERICIDAL AGENT 日本曹達株式会社 2024-07-04 WO disclosed
EP-2773617-B1 PESTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-08-22 EP disclosed
EP-3210469-A1 USE OF SUBSTITUTED THIO-1,2,4-TRIAZOLES FOR INCREASING STRESS TOLERANCE IN PLANTS Bayer Cropscience AG (DE) 2017-08-30 EP disclosed
US-9227955-B2 Compound having angiogenesis inhibitory activity, method for preparing same, and pharmaceutical composition comprising same BORYUNG PHARMACEUTICAL CO., LTD. (KR) 2016-01-05 US disclosed
US-20150223456-A1 PESTICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2015-08-13 US disclosed
US-9040708-B2 Pesticidal compounds SYNGENTA LIMITED (GB) 2015-05-26 US disclosed
US-20140296067-A1 PESTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2014-10-02 US disclosed
EP-0272221-A2 Process for the preparation of substituted pyridines CIBA-GEIGY AG (CH) 1988-06-22 EP disclosed
US-4742060-A 2-(NITROIMINO)- OR 2-(NITROMETHYLENE)-IMIDAZOLIDINES AS INSECTICIDES NIHON TOKUSHU NOYAKU SEIZO K. K. (JP) 1988-05-03 US disclosed
US-4678795-A 1-pyridylmethyl-2-nitromethylene-1,3-diazacycloalkane insecticides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1987-07-07 US disclosed
EP-0192060-A1 Heterocyclic compounds NIHON BAYER AGROCHEM K.K. (JP) 1986-08-27 EP disclosed
EP-0163855-A1 Nitromethylene derivatives, intermediates, and process for their preparation as insecticides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1985-12-11 EP disclosed
US-4521603-A Continuous process for the production of polybromopyridine compounds OLIN CORPORATION (US) 1985-06-04 US disclosed
US-3974166-A FUNGICIDE CIBA-GEIGY CORPORATION (US) 1976-08-10 US disclosed
US-3956340-A Process for the production of polyhalogenated nicotinic acids CIBA-GEIGY CORPORATION (US) 1976-05-11 US disclosed
US-3956340-A Process for the production of polyhalogenated nicotinic acids CIBA-GEIGY CORPORATION (US) 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150223456-A1 PESTICIDAL COMPOUNDS C5, CBR3, C3AR1 KMT2A 4358/4885NPSR1 357/4885ALDH1A1 1233/4885
US-20140296067-A1 PESTICIDAL COMPOUNDS C5, CBR3, C3AR1 KMT2A 4358/4885NPSR1 357/4885ALDH1A1 1233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.