CTRC — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL948869	0.49	6/20
SCHEMBL196710	0.43	5/20
SCHEMBL476659	0.62	4/20
SCHEMBL730762	0.60	4/20
SCHEMBL730756	0.55	4/20
SCHEMBL571617	0.51	4/20
SCHEMBL305339	0.47	4/20
SCHEMBL473208	0.43	4/20
SCHEMBL473210	0.43	4/20
SCHEMBL895720	0.42	4/20
SCHEMBL475256	0.42	4/20
SCHEMBL475258	0.42	4/20
SCHEMBL895769	0.41	4/20
SCHEMBL894030	0.38	4/20
SCHEMBL895779	0.38	4/20
SCHEMBL895781	0.38	4/20
SCHEMBL896043	0.38	4/20
SCHEMBL894889	0.37	4/20
SCHEMBL895114	0.37	4/20
SCHEMBL895152	0.37	4/20

Clinical trials — most relevant to CTRC by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Activated Protein C in Severe Acute Pancreatitis	PHASE4	COMPLETED
Effect of Renin-angiotensin-system Blockade on Urinary Free Light Chains in Patients With Type 2 Diabetes Mellitus	PHASE4	COMPLETED
Brain Natriuretic Peptide (BNP) to Preserve Renal Function in Hospitalized Patients With Heart Failure	PHASE3	COMPLETED
A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis	PHASE1/PHASE2	COMPLETED
A Research Study to See How a New Medicine (NNC0487-0111) Works in People With Overweight or Obesity When Injected Under the Skin	PHASE2	COMPLETED
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis	PHASE1/PHASE2	COMPLETED
A Research Study on How NNC0487-0111 Works in People With Overweight or Obesity	PHASE1	COMPLETED
A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants After 10 Days of Oral Dosing	PHASE1	COMPLETED
A Study on How NNC0174-1213 Works in People With Overweight or Obesity.	PHASE1	RECRUITING
Serum Cystatin C for Early Detection of Acute Kidney Injury After Primary Percutaneous Coronary Intervention	nan	NOT_YET_RECRUITING
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Proteomic Pattern in Female Stress Urinary Incontinence: a Pilot Study	nan	COMPLETED
Birth Control Pill vs Birth Control Patch Study	nan	COMPLETED
Pancreas Volume in Preclinical Type 1 Diabetes	nan	COMPLETED
Novel Breath Test to Detect Early Stage Chronic Pancreatitis	nan	COMPLETED
Molecular Content of Peri-implant Sulcus During Wound Healing and Osseointegration Following Drilling and Piezosurgery	nan	COMPLETED
Impact of Non Surgical Periodontal Therapy on Cystatin C Levels	nan	COMPLETED
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery	nan	RECRUITING
Pharmacokinetics of Ciprofloxacin in Critically Ill Patients	nan	COMPLETED
Long-term Health After Severe Acute Malnutrition in Children and Adults: the Role of the Pancreas	nan	COMPLETED
Effect of Fluid Regimen on Acute Kidney Injury	nan	COMPLETED
Stroke Risk Assessment and Markers of Blood Clotting in Patients With Newly Diagnosed Non-valvular Atrial Fibrillation (NVAF), Who Have Not Received Oral Anticoagulation Therapy (OAC-therapy) Prior to Inclusion	nan	RECRUITING
Exocrine Pancreatic Function Testing in Cystic Fibrosis	nan	UNKNOWN
The Diagnosis of Chronic Pancreatitis	nan	UNKNOWN
Pancreatic Exocrine Insufficiency in Acute Pancreatitis	nan	COMPLETED
Utilization of CBC-Derived Inflammatory Indices in Assessing Severity and Prognosis of Acute Pancreatitis.	nan	NOT_YET_RECRUITING
Validation Of Chronic Pancreatitis Prognosis Score (COPPS)	nan	COMPLETED
Impact of Long-term Protease Inhibitors in Patients Living With HIV on the Incidence of COVID-19 ( COVIP )	nan	COMPLETED
Presepsin as a Predictor for Postoperative Complications Following Pancreatic Resection	nan	COMPLETED
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a CTRC binder may also engage these)

Protein	Name	Similarity
P55091	—	0.993	P55091 →
Q3SYP2	—	0.987	Q3SYP2 →
P05805	—	0.987	P05805 →
Q7M3E1	—	0.986	Q7M3E1 →
P08861	—	0.983	P08861 →
O19023	—	0.983	O19023 →
P09093	—	0.981	P09093 →
Q7M4I3	—	0.975	Q7M4I3 →
Q9CQ52	—	0.971	Q9CQ52 →
P08218	—	0.971	P08218 →
B5U2W0	—	0.967	B5U2W0 →
P00759	—	0.966	P00759 →
P00756	—	0.966	P00756 →
Q29461	—	0.965	Q29461 →
P08419	—	0.965	P08419 →
Q867B0	—	0.964	Q867B0 →
Q8NHM4	—	0.962	Q8NHM4 →
P15947	—	0.962	P15947 →
P36375	—	0.961	P36375 →
P08217	—	0.961	P08217 →
Q5R1M5	—	0.961	Q5R1M5 →
P00769	—	0.960	P00769 →
P21902	—	0.960	P21902 →
P15949	—	0.960	P15949 →
P80009	—	0.960	P80009 →
O46644	—	0.960	O46644 →
P15946	—	0.960	P15946 →
Q9GL10	—	0.959	Q9GL10 →
P32824	—	0.959	P32824 →
P05208	—	0.959	P05208 →