Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13990620 | 0.81 | PLAT (0.48) | PLATMAPTNPC1RAB9AMEN1 | |
| SCHEMBL13153943 | 0.73 | KDM4E (0.31) | KDM4EBRD4CREBBP | |
| SCHEMBL13516747 | 0.72 | PLAT (0.43) | PLATNPC1 | |
| SCHEMBL8685707 | 0.71 | KDR (0.39) | PLATMAPTNPC1RAB9AMEN1 | |
| SCHEMBL19926063 | 0.70 | MEN1 (0.40) | PLATMAPTNPC1RAB9AMEN1 | |
| SCHEMBL170616 | 0.69 | KDM4D (0.40) | PLATMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL19927200 | 0.69 | KDM4E (0.42) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL4048020 | 0.68 | HPGD (0.52) | PLATRAB9AKDM4EALDH1A1HPGD | |
| SCHEMBL19927088 | 0.66 | PARP1 (0.52) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL25248458 | 0.60 | MAPT (0.50) | MAPTRAB9AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | disclosed |