Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 18/20 | 0.53 |
| ▸ | AKT2 | P31751 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2893852 | 0.87 | JAK2 (0.55) | JAK2AKT1AKT2KCNH2HRH2 | |
| SCHEMBL12132974 | 0.86 | JAK2 (0.48) | JAK2AKT1AKT2KCNH2 | |
| SCHEMBL1501534 | 0.86 | AKT1 (0.54) | JAK2AKT1AKT2KCNH2HRH2 | |
| SCHEMBL2898785 | 0.84 | JAK2 (0.58) | JAK2AKT1AKT2KCNH2HRH2 | |
| SCHEMBL2898847 | 0.84 | JAK2 (0.54) | JAK2AKT1AKT2KCNH2 | |
| SCHEMBL5528216 | 0.84 | JAK2 (0.54) | JAK2AKT1AKT2KCNH2HRH2 | |
| SCHEMBL2893676 | 0.83 | JAK2 (0.52) | JAK2AKT1AKT2KCNH2HRH2 | |
| SCHEMBL18203546 | 0.83 | JAK2 (0.55) | JAK2AKT1AKT2KCNH2 | |
| SCHEMBL1351051 | 0.83 | AKT1 (0.52) | JAK2AKT1AKT2KCNH2HRH2 | |
| SCHEMBL12759277 | 0.83 | AKT1 (0.52) | JAK2AKT1AKT2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |