Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 11/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 11/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15049710 | 0.90 | F11 (0.40) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL965131 | 0.79 | F11 (0.42) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL961002 | 0.77 | F11 (0.38) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL961001 | 0.77 | F11 (0.38) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL960931 | 0.76 | F11 (0.35) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL964618 | 0.76 | PSEN1 (0.42) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL963648 | 0.71 | UGT1A1 (0.42) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL960134 | 0.69 | PSEN1 (0.41) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL961832 | 0.66 | UGT1A1 (0.45) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL961599 | 0.66 | PSEN1 (0.46) | F11KLKB1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083141-A1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-22 | — | — | WO | disclosed |