Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784901 | 0.75 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL2017369 | 0.74 | KMT2A (0.71) | SMN1; SMN2KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL1310923 | 0.74 | KDM4E (0.47) | SMN1; SMN2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL13556619 | 0.74 | TSHR (0.51) | SMN1; SMN2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL4152010 | 0.73 | KMT2A (0.56) | SMN1; SMN2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL4011505 | 0.72 | KMT2A (0.55) | SMN1; SMN2KMT2AMEN1AURKBMAPT | |
| SCHEMBL440425 | 0.72 | KMT2A (0.68) | SMN1; SMN2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL3784898 | 0.72 | KDM4E (0.48) | SMN1; SMN2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL20951987 | 0.72 | KMT2A (0.43) | SMN1; SMN2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL3066037 | 0.72 | KMT2A (0.54) | SMN1; SMN2KMT2AMEN1AURKBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298302-A1 | NOVEL PROTEIN KINASE MODULATORS | SENHWA BIOSCIENCES, INC. (TW) | 2010-11-25 | — | — | US | disclosed |
| WO-2010135571-A1 | NOVEL PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298302-A1 | NOVEL PROTEIN KINASE MODULATORS | PIM2, PIM1, PIM3 | SMN1; SMN2 4553/4885KMT2A 1473/4885MEN1 4370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.