Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1310922 | 0.80 | PTPN2 (0.53) | SMN1; SMN2ELANEKDM4EALDH1A1HPGD | |
| SCHEMBL3790221 | 0.77 | CDC25B (0.44) | SMN1; SMN2ELANEKDM4EMAPTNPSR1 | |
| SCHEMBL3784898 | 0.77 | KDM4E (0.48) | SMN1; SMN2KDM4ENPSR1ALDH1A1HPGD | |
| SCHEMBL3790285 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL16516735 | 0.75 | KDM4E (0.54) | SMN1; SMN2ELANEKDM4ENPSR1ALDH1A1 | |
| SCHEMBL2783523 | 0.74 | NPBWR1 (0.48) | SMN1; SMN2KDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL21439743 | 0.74 | SPR (0.53) | SMN1; SMN2ELANEKDM4EALDH1A1CYP1A2 | |
| SCHEMBL24455539 | 0.73 | CYP1A2 (0.42) | SMN1; SMN2ELANEKDM4EMAPTNPSR1 | |
| SCHEMBL8568089 | 0.72 | CA12 (0.48) | SMN1; SMN2KDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL2779501 | 0.72 | MAP3K5 (0.46) | SMN1; SMN2KDM4EMAPTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135571-A1 | NOVEL PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| US-20100298302-A1 | NOVEL PROTEIN KINASE MODULATORS | SENHWA BIOSCIENCES, INC. (TW) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298302-A1 | NOVEL PROTEIN KINASE MODULATORS | PIM2, PIM1, PIM3 | SMN1; SMN2 4553/4885ELANE 4586/4885KDM4E 1746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.