Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 9/20 | 0.68 |
| ▸ | CDK4 | P11802 | 5/20 | 0.58 |
| ▸ | AURKA | O14965 | 4/20 | 0.58 |
| ▸ | CCND1 | P24385 | 2/20 | 0.56 |
| ▸ | CCND2 | P30279 | 2/20 | 0.56 |
| ▸ | CCND3 | P30281 | 2/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15163242 | 0.90 | STAT6 (0.67) | STAT6CDK4AURKACCND1CCND2 | |
| SCHEMBL3711062 | 0.89 | STAT6 (0.58) | STAT6CDK4AURKACCND3RPS6KA3 | |
| SCHEMBL1284873 | 0.89 | STAT6 (0.55) | STAT6CDK4AURKACCND1CCND2 | |
| SCHEMBL3790567 | 0.85 | STAT6 (0.65) | STAT6CDK4AURKACCND1CCND2 | |
| SCHEMBL3711931 | 0.84 | JAK2 (0.53) | STAT6CDK4CCND1CCND3CDK1 | |
| SCHEMBL15163089 | 0.83 | STAT6 (0.62) | STAT6CDK4AURKACCND1CCND2 | |
| SCHEMBL3711049 | 0.82 | JAK3 (0.49) | STAT6JAK2AURKBKDRIGF1R | |
| SCHEMBL1284538 | 0.81 | TBK1 (0.71) | STAT6CDK4AURKACCND1CCND2 | |
| SCHEMBL3718766 | 0.80 | PAK1 (0.49) | STAT6CDK4AURKACCND1CCND2 | |
| SCHEMBL3795187 | 0.80 | TBK1 (0.70) | STAT6AURKARPS6KA3SYKCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |