Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4886616 | 0.94 | POLB (0.43) | LMNAPOLBCYP3A4NPC1HTT | |
| SCHEMBL14948208 | 0.86 | POLB (0.45) | LMNAPOLBCYP3A4NPC1HTT | |
| SCHEMBL13379278 | 0.84 | POLB (0.43) | POLBCYP3A4NPC1HTTMEN1 | |
| SCHEMBL3201584 | 0.83 | SIRT3 (0.47) | LMNAPOLBCYP3A4NPC1HTT | |
| SCHEMBL3449786 | 0.83 | ALDH1A1 (0.51) | LMNAPOLBCYP3A4NPC1HTT | |
| SCHEMBL14407244 | 0.82 | POLB (0.43) | LMNAPOLBCYP3A4NPC1HTT | |
| SCHEMBL14073384 | 0.81 | TSHR (0.48) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL26456333 | 0.81 | SIRT3 (0.49) | POLBCYP3A4NPC1HTTMEN1 | |
| SCHEMBL3039333 | 0.80 | POLB (0.50) | LMNAPOLBCYP3A4NPC1HTT | |
| SCHEMBL14405897 | 0.79 | ALDH1A1 (0.39) | LMNAMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741014-B2 | Patterning and alteration of molecules | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-06-22 | — | — | US | disclosed |
| US-20070000866-A1 | Patterning and alteration of molecules | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-01-04 | — | — | US | disclosed |
| US-20060138083-A1 | Patterning and alteration of molecules | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-06-29 | — | — | US | disclosed |