Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 8/20 | 0.43 |
| ▸ | WEE1 | P30291 | 3/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PAK4 | O96013 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790694 | 0.85 | JAK3 (0.50) | CDC7JAK3RPS6KA3STAT6KDR | |
| SCHEMBL15163177 | 0.82 | TBK1 (0.51) | CDC7JAK3RPS6KA3STAT6KDR | |
| SCHEMBL1284474 | 0.80 | TBK1 (0.65) | CDC7JAK3IKBKETBK1AURKB | |
| SCHEMBL15163166 | 0.80 | RPS6KA3 (0.47) | JAK3RPS6KA3STAT6KDRALK | |
| SCHEMBL3716518 | 0.79 | RPS6KA3 (0.49) | CDC7JAK3RPS6KA3STAT6KDR | |
| SCHEMBL3719414 | 0.79 | PTK2 (0.45) | JAK3RPS6KA3STAT6KDRALK | |
| SCHEMBL3721787 | 0.78 | RPS6KA3 (0.48) | JAK3RPS6KA3STAT6KDRALK | |
| SCHEMBL15163478 | 0.78 | CDK4 (0.53) | CDC7JAK3RPS6KA3STAT6KDR | |
| SCHEMBL3714024 | 0.76 | RPS6KA3 (0.48) | JAK3RPS6KA3STAT6KDRALK | |
| SCHEMBL3715010 | 0.76 | PTK2 (0.48) | JAK3RPS6KA3STAT6KDRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | claimed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | claimed |
| EP-2403853-B1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2013-08-14 | — | — | EP | disclosed |
| WO-2010100431-A1 | PYRROLOPYRIMIDINES USED AS KINASE INHIBITORS | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2010-09-10 | — | — | WO | disclosed |