Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.60 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL339062 | 0.97 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL2351951 | 0.97 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3790706 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3790705 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL872578 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL872580 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3791421 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL2459164 | 0.92 | CYP3A4 (0.65) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL9755176 | 0.92 | CYP3A4 (0.65) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL15527809 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9234125-B2 | Corrosion inhibitor systems for low, moderate and high temperature fluids and methods for making and using same | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2016-01-12 | — | — | US | disclosed |
| US-20140128294-A1 | CORROSION INHIBITOR SYSTEMS FOR LOW, MODERATE AND HIGH TEMPERATURE FLUIDS AND METHODS FOR MAKING AND USING SAME | WEATHERFORD/LAMB, INC. (US) | 2014-05-08 | — | — | US | disclosed |
| US-8563481-B2 | Corrosion inhibitor systems for low, moderate and high temperature fluids and methods for making and using same | CLEARWATER INTERNATIONAL LLC (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120302468-A1 | FORMULATIONS AND USES OF DRILLING FLUIDS CONTAINING VISCOSIFIED PHOSPHATE BRINE | CLEARWATER INTERNATIONAL, LLC (US) | 2012-11-29 | — | — | US | disclosed |
| US-20120295820-A1 | MANAGEMENT OF CORROSION IN PHOSPHATE BRINES | CLEARWATER INTERNATIONAL, LLC (US) | 2012-11-22 | — | — | US | disclosed |
| EP-2264119-A1 | High density phosphate brines and methods for making and using same | Clearwater International LLC (US) | 2010-12-22 | — | — | EP | disclosed |
| US-20100305010-A1 | HIGH DENSITY PHOSPHATE BRINES AND METHODS FOR MAKING AND USING SAME | CLEARWATER INTERNATIONAL, LLC (US) | 2010-12-02 | — | — | US | disclosed |
| US-7566686-B2 | Shale inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, LLC (US) | 2009-07-28 | — | — | US | disclosed |
| US-20080039345-A1 | Shale inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, L.L.C. | 2008-02-14 | — | — | US | disclosed |
| US-7268100-B2 | Shale inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, LLC (US) | 2007-09-11 | — | — | US | disclosed |
| US-20060194700-A1 | Corrosion inhibitor systems for low, moderate and high temperature fluids and methods for making and using same | WEATHERFORD/LAMB | 2006-08-31 | — | — | US | disclosed |
| US-20060116296-A1 | Shale Inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, L.L.C. | 2006-06-01 | — | — | US | disclosed |