Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.60 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRK2 | P25098 | 1/20 | 0.36 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL339062 | 0.92 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL2351951 | 0.92 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL339064 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3790708 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3790705 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL872578 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3790706 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3791421 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL872580 | 0.90 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL31591121 | 0.89 | MEN1 (0.67) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260015560-A1 | COMPOSITIONS FOR POST-CMP CLEANING OF MICROELECTRONIC DEVICES | ENTEGRIS INC (US) | 2026-01-15 | — | — | US | claimed |
| CN-117069901-A | Lignin-based phenolic resin and preparation method thereof | 江苏理文造纸有限公司 | 2023-11-17 | — | — | CN | claimed |
| EP-3244987-B1 | SEPARATIONS WITH IONIC LIQUID SOLVENTS | CHEVRON PHILLIPS CHEMICAL CO LP (US) | 2022-06-22 | — | — | EP | claimed |
| US-10227274-B2 | Separations with ionic liquid solvents | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2019-03-12 | — | — | US | claimed |
| EP-3244987-A1 | SEPARATIONS WITH IONIC LIQUID SOLVENTS | Chevron Phillips Chemical Company LP (US) | 2017-11-22 | — | — | EP | claimed |
| US-9238611-B2 | Process for separating aryl carboxylic acids | RELIANCE INDUSTRIES LIMITED (IN) | 2016-01-19 | — | — | US | claimed |
| WO-2015166507-A1 | A PROCESS FOR PRODUCING AROMATIC DICARBOXYLIC ACIDS | RELIANCE INDUSTRIES LIMITED (IN) | 2015-11-05 | — | — | WO | claimed |
| US-20150133711-A1 | Separations With Ionic Liquid Solvents | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2015-05-14 | — | — | US | claimed |
| US-20150065748-A1 | PROCESS FOR SEPARATING ARYL CARBOXYLIC ACIDS | RELIANCE INDUSTRIES LIMITED (IN) | 2015-03-05 | — | — | US | claimed |
| EP-2831027-A1 | A PROCESS FOR SEPARATING ARYL CARBOXYLIC ACIDS | Reliance Industries Limited (IN) | 2015-02-04 | — | — | EP | claimed |
| WO-2013164852-A1 | A PROCESS FOR SEPARATING ARYL CARBOXYLIC ACIDS | RELIANCE INDUSTRIES LIMITED (IN) | 2013-11-07 | — | — | WO | claimed |
| EP-4493623-B1 | PET DEPOLYMERIZATION PROCESS | REPET S R L (IT) | 2026-01-21 | — | — | EP | disclosed |
| US-20260015560-A1 | COMPOSITIONS FOR POST-CMP CLEANING OF MICROELECTRONIC DEVICES | ENTEGRIS INC (US) | 2026-01-15 | — | — | US | disclosed |
| US-20250090437-A1 | COSMETIC COMPOUNDING AGENT, COSMETIC AND PRODUCTION METHOD THEREOF | MIYOSHI YUSHI KK (JP) | 2025-03-20 | — | — | US | disclosed |
| EP-3345965-B1 | ANTI-STATIC BICOMPONENT FORMULATION FOR UNSATURATED POLYESTER RESINS AND EPOXY VINYL ESTER RESINS | AVANZARE INNOVACION TECNOLOGICA S L (ES) | 2025-01-01 | — | — | EP | disclosed |
| CN-104805135-A | Whole-cell catalytic synthesis method of vanilline | UNIV SHENZHEN | 2015-07-29 | — | — | CN | disclosed |
| US-20150133711-A1 | Separations With Ionic Liquid Solvents | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2015-05-14 | — | — | US | disclosed |
| US-20150065748-A1 | PROCESS FOR SEPARATING ARYL CARBOXYLIC ACIDS | RELIANCE INDUSTRIES LIMITED (IN) | 2015-03-05 | — | — | US | disclosed |
| EP-2831027-A1 | A PROCESS FOR SEPARATING ARYL CARBOXYLIC ACIDS | Reliance Industries Limited (IN) | 2015-02-04 | — | — | EP | disclosed |
| WO-2013164852-A1 | A PROCESS FOR SEPARATING ARYL CARBOXYLIC ACIDS | RELIANCE INDUSTRIES LIMITED (IN) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260015560-A1 | COMPOSITIONS FOR POST-CMP CLEANING OF MICROELECTRONIC DEVICES | TET2, ASIC1, PIEZO1 | MEN1 2976/4885KMT2A 778/4885LMNA 2078/4885 |
| US-20250090437-A1 | COSMETIC COMPOUNDING AGENT, COSMETIC AND PRODUCTION METHOD THEREOF | CUTA, HAT1, NACA | MEN1 643/4885KMT2A 961/4885LMNA 3747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.