Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.36 |
| ▸ | TUBB | P07437 | 2/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15906122 | 0.82 | POLB (0.46) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3794588 | 0.81 | MAPT (0.44) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| Hydrochloric Acid SCHEMBL3790264 | 0.80 | MAPT (0.44) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8055713 | 0.79 | HDAC8 (0.44) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4316362 | 0.78 | RXFP1 (0.46) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3797522 | 0.78 | ALDH1A1 (0.50) | MAPTPOLBNPC1SMN1; SMN2RAB9A | |
| SCHEMBL3786448 | 0.78 | MAPK1 (0.48) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL13578421 | 0.78 | MAPT (0.41) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3794087 | 0.77 | PDE4D (0.58) | MAPTTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3470072 | 0.73 | PDE4B (0.38) | MAPTTSHRNPC1SMN1; SMN2PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222638-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |