Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 11/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725466 | 0.88 | EPHX2 (0.46) | PPARGEPHX2ROCK2ROCK1BRD4 | |
| SCHEMBL3798181 | 0.88 | EPHX2 (0.49) | PPARGEPHX2ROCK2ROCK1HSD17B13 | |
| SCHEMBL13076709 | 0.87 | EPHX2 (0.49) | PPARGEPHX2ROCK2ROCK1BRD4 | |
| SCHEMBL13076471 | 0.86 | EPHX2 (0.44) | PPARGEPHX2ROCK2ROCK1BRD4 | |
| SCHEMBL13076520 | 0.86 | EPHX2 (0.42) | PPARGEPHX2ROCK2ROCK1BRD4 | |
| SCHEMBL3793409 | 0.86 | ROCK2 (0.46) | PPARGEPHX2ROCK2ROCK1BRD4 | |
| SCHEMBL13075684 | 0.86 | EPHX2 (0.46) | PPARGEPHX2ROCK2ROCK1BRD4 | |
| SCHEMBL13076714 | 0.86 | EPHX2 (0.42) | PPARGEPHX2ROCK2ROCK1BRD4 | |
| SCHEMBL13075744 | 0.85 | EPHX2 (0.50) | PPARGEPHX2ROCK2ROCK1BRD4 | |
| SCHEMBL13075745 | 0.85 | EPHX2 (0.46) | PPARGEPHX2ROCK2ROCK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010129848-A2 | 2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXAMIDES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-11 | — | — | WO | disclosed |