Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cyclamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclamic Acid SCHEMBL4602644 | 0.89 | CA1 (0.54) | CA1CA12CA7CA14CA2 | |
| Cyclamic Acid SCHEMBL18585752 | 0.89 | CA12 (0.64) | CA1CA12CA7CA14CA2 | |
| SCHEMBL1726858 | 0.89 | CA12 (0.64) | CA1CA12CA7CA14CA2 | |
| SCHEMBL1727915 | 0.89 | CA12 (0.64) | CA1CA12CA7CA14CA2 | |
| SCHEMBL1726879 | 0.89 | CA12 (0.64) | CA1CA12CA7CA14CA2 | |
| Cyclamic Acid SCHEMBL6227 | 0.89 | CA12 (0.64) | CA1CA12CA7CA14CA2 | |
| SCHEMBL1727205 | 0.89 | CA12 (0.64) | CA1CA12CA7CA14CA2 | |
| Cyclamic Acid SCHEMBL11686696 | 0.89 | CA12 (0.64) | CA1CA12CA7CA14CA2 | |
| Cyclamic Acid SCHEMBL120573 | 0.87 | CA12 (0.61) | CA1CA12CA7CA14CA2 | |
| Cyclamic Acid SCHEMBL8532680 | 0.87 | CA12 (0.61) | CA1CA12CA7CA14CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551762-B1 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | DANISCO US INC (US) | 2010-10-27 | — | — | EP | claimed |
| US-20080182971-A1 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | GENENCOR INTERNATIONAL, INC. (US) | 2008-07-31 | — | — | US | claimed |
| US-7361731-B2 | Peptide derivatives, and their use for the synthesis of silicon-based composite materials | GENENCOR INTERNATIONAL, INC. (US) | 2008-04-22 | — | — | US | claimed |
| EP-1551762-A4 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | DOW CORNING (US) | 2008-04-16 | — | — | EP | claimed |
| EP-1551762-A2 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | Dow Corning Corporation (US) | 2005-07-13 | — | — | EP | claimed |
| US-20040039179-A1 | Peptide derivatives, and their use for the synthesis of silicon-based composite materials | DANISCO US INC. | 2004-02-26 | — | — | US | claimed |
| WO-2003099843-A2 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | DOW CORNING CORPORATION (US) | 2003-12-04 | — | — | WO | claimed |
| EP-1551762-B1 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | DANISCO US INC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-20080182971-A1 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | GENENCOR INTERNATIONAL, INC. (US) | 2008-07-31 | — | — | US | disclosed |
| US-7361731-B2 | Peptide derivatives, and their use for the synthesis of silicon-based composite materials | GENENCOR INTERNATIONAL, INC. (US) | 2008-04-22 | — | — | US | disclosed |
| EP-1551762-A4 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | DOW CORNING (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1551762-A2 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | Dow Corning Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| US-20040039179-A1 | Peptide derivatives, and their use for the synthesis of silicon-based composite materials | DANISCO US INC. | 2004-02-26 | — | — | US | disclosed |
| WO-2003099843-A2 | PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS | DOW CORNING CORPORATION (US) | 2003-12-04 | — | — | WO | disclosed |