Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.51 |
| ▸ | CNR1 | P21554 | 9/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13256989 | 1.00 | CNR2 (0.51) | CNR2CNR1KCNK3LMNAHSD11B1 | |
| SCHEMBL13256997 | 0.86 | CNR2 (0.48) | CNR2CNR1KCNK3LMNAJAK1 | |
| SCHEMBL16239264 | 0.83 | CNR1 (0.42) | CNR2CNR1SMN1; SMN2 | |
| SCHEMBL16254983 | 0.81 | CNR2 (0.52) | CNR2CNR1KCNK3LMNAHSD11B1 | |
| SCHEMBL13256796 | 0.79 | CNR2 (0.52) | CNR2CNR1LMNAHSD11B1POLB | |
| SCHEMBL13284561 | 0.79 | CNR2 (0.52) | CNR2CNR1KCNK3LMNAHSD11B1 | |
| SCHEMBL13257045 | 0.77 | ALDH1A1 (0.58) | CNR2CNR1HSD11B1POLBTSHR | |
| SCHEMBL13257194 | 0.77 | CNR2 (0.57) | CNR2CNR1LMNAHSD11B1POLB | |
| SCHEMBL13256788 | 0.76 | SMN1; SMN2 (0.60) | CNR2CNR1LMNASMN1; SMN2KDM4E | |
| SCHEMBL3711811 | 0.76 | MEN1 (0.54) | CNR2LMNAJAK2POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398771-A2 | HETEROCYCLIC COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | Boehringer Ingelheim International GmbH (DE) | 2011-12-28 | — | — | EP | claimed |
| WO-2010096371-A2 | HETEROCYCLIC COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-26 | — | — | WO | claimed |