Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HSD17B13 | Q7Z5P4 | 3/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796727 | 0.91 | EPHX2 (0.52) | PPARGEPHX2ROCK2ROCK1RIPK1 | |
| SCHEMBL13258052 | 0.90 | EPHX2 (0.49) | PPARGEPHX2ROCK2ROCK1RIPK1 | |
| SCHEMBL3788362 | 0.90 | EPHX2 (0.49) | PPARGEPHX2ROCK2ROCK1RIPK1 | |
| SCHEMBL3791605 | 0.90 | EPHX2 (0.49) | PPARGEPHX2ROCK2ROCK1RIPK1 | |
| SCHEMBL3786599 | 0.90 | EPHX2 (0.48) | PPARGEPHX2ROCK2ROCK1RIPK1 | |
| SCHEMBL3786760 | 0.90 | EPHX2 (0.48) | PPARGEPHX2ROCK2ROCK1RIPK1 | |
| SCHEMBL3794154 | 0.89 | EPHX2 (0.52) | PPARGEPHX2ROCK2ROCK1RIPK1 | |
| SCHEMBL3788636 | 0.89 | EPHX2 (0.48) | PPARGEPHX2ROCK2ROCK1RIPK1 | |
| SCHEMBL3811009 | 0.89 | EPHX2 (0.48) | PPARGEPHX2ROCK2ROCK1RIPK1 | |
| SCHEMBL3807116 | 0.89 | PPARG (0.47) | PPARGEPHX2ROCK2ROCK1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |