Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.79 |
| ▸ | JAK2 | O60674 | 3/20 | 0.70 |
| ▸ | LCK | P06239 | 3/20 | 0.70 |
| ▸ | LYN | P07948 | 3/20 | 0.70 |
| ▸ | KIT | P10721 | 3/20 | 0.70 |
| ▸ | TEC | P42680 | 3/20 | 0.70 |
| ▸ | TXK | P42681 | 3/20 | 0.70 |
| ▸ | BMX | P51813 | 3/20 | 0.70 |
| ▸ | ITK | Q08881 | 3/20 | 0.70 |
| ▸ | CDK2 | P24941 | 2/20 | 0.70 |
| ▸ | AURKA | O14965 | 2/20 | 0.63 |
| ▸ | TYK2 | P29597 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3780396 | 0.89 | BTK (0.63) | BTKJAK2LCKLYNKIT | |
| SCHEMBL122287 | 0.88 | BTK (1.00) | BTKJAK2LCKLYNKIT | |
| SCHEMBL123348 | 0.83 | BTK (1.00) | BTKJAK2LCKLYNKIT | |
| SCHEMBL123351 | 0.82 | BTK (0.81) | BTKJAK2LCKLYNKIT | |
| SCHEMBL27982102 | 0.82 | BTK (0.82) | BTKJAK2LCKLYNKIT | |
| SCHEMBL27982092 | 0.81 | BTK (0.72) | BTKJAK2LCKLYNKIT | |
| SCHEMBL27982678 | 0.81 | BTK (0.87) | BTKJAK2LCKLYNKIT | |
| SCHEMBL27982112 | 0.81 | BTK (0.72) | BTKJAK2LCKLYNKIT | |
| SCHEMBL3793045 | 0.81 | BTK (0.67) | BTKJAK2LCKLYNKIT | |
| SCHEMBL27982595 | 0.81 | BTK (0.74) | BTKJAK2LCKLYNKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391602-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010080481-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |