Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | TEC | P42680 | 1/20 | 0.44 |
| ▸ | TXK | P42681 | 1/20 | 0.44 |
| ▸ | BMX | P51813 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123224 | 0.88 | BTK (0.71) | BTKJAK2LCKLYNKIT | |
| SCHEMBL3780396 | 0.82 | BTK (0.63) | BTKJAK2LCKLYNKIT | |
| SCHEMBL3791083 | 0.81 | BTK (0.79) | BTKJAK2LCKLYNKIT | |
| SCHEMBL19279052 | 0.80 | BTK (1.00) | BTKTECTXKBMXITK | |
| SCHEMBL148176 | 0.79 | BTK (0.73) | BTK | |
| SCHEMBL28814137 | 0.76 | BTK (0.61) | BTKJAK2LCKLYNKIT | |
| SCHEMBL3782694 | 0.72 | BTK (0.63) | BTKJAK2LCKLYNKIT | |
| SCHEMBL124414 | 0.71 | BTK (0.75) | BTKJAK2LCKLYNKIT | |
| SCHEMBL122332 | 0.71 | BTK (0.80) | BTKJAK2LCKLYNKIT | |
| SCHEMBL3788132 | 0.71 | BTK (0.70) | BTKJAK2LCKLYNKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391602-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010080481-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |