Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 20/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3798163 | 0.93 | PTGES (0.51) | PTGESJAK2 | |
| SCHEMBL3793767 | 0.91 | PTGES (0.45) | PTGESJAK2 | |
| SCHEMBL3794308 | 0.86 | PTGES (0.47) | PTGESJAK2 | |
| SCHEMBL3719623 | 0.85 | PTGES (0.46) | PTGESJAK2 | |
| SCHEMBL3801685 | 0.84 | PTGES (0.51) | PTGESJAK2 | |
| SCHEMBL3792479 | 0.83 | PTGES (0.41) | PTGESJAK2 | |
| SCHEMBL13075539 | 0.82 | PTGES (0.52) | PTGESJAK2 | |
| SCHEMBL3801553 | 0.82 | PTGES (0.40) | PTGESJAK2 | |
| SCHEMBL3796802 | 0.82 | PTGES (0.42) | PTGESJAK2 | |
| SCHEMBL3794452 | 0.82 | PTGES (0.44) | PTGESJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |