Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 3/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.35 |
| ▸ | FECH | P22830 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457587 | 0.85 | AKT1 (0.38) | AKT1MAPTKDM4EALDH1A1POLB | |
| SCHEMBL3791392 | 0.83 | RAF1 (0.38) | AKT1MAPTKDM4EALDH1A1POLB | |
| SCHEMBL1351885 | 0.82 | SGK1 (0.43) | AKT1MAPTKDM4EALDH1A1POLB | |
| SCHEMBL1350719 | 0.82 | AKT1 (0.64) | AKT1AKT2AKT3FECH | |
| SCHEMBL27735507 | 0.82 | L3MBTL1 (0.37) | AKT1MAPTKDM4EALDH1A1POLB | |
| SCHEMBL3781768 | 0.82 | AKT1 (0.39) | AKT1KDM4EALDH1A1ADKAKT2 | |
| SCHEMBL3785540 | 0.82 | AKT1 (0.39) | AKT1KDM4EADKAKT2AKT3 | |
| SCHEMBL3784812 | 0.82 | MEN1 (0.40) | AKT1ADKAKT2AKT3FECH | |
| Hydrochloric Acid SCHEMBL1349873 | 0.81 | AKT1 (0.62) | AKT1AKT2AKT3FECH | |
| SCHEMBL2281711 | 0.80 | GSK3B (0.39) | AKT1MAPTKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104669-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2014-10-15 | — | — | EP | disclosed |
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |
| EP-2104669-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008070041-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008070016-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2008-06-12 | — | — | WO | disclosed |