Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 5/20 | 0.52 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.48 |
| ▸ | PLK1 | P53350 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | BMX | P51813 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913839 | 0.79 | EGFR (0.57) | SCN9AMAP3K5SYKJAK3ITK | |
| SCHEMBL27075736 | 0.76 | AURKA (0.73) | AURKAAURKBSRCJAK2NPC1 | |
| SCHEMBL27075731 | 0.76 | AURKA (0.61) | AURKAAURKBSRCJAK2MAP3K5 | |
| SCHEMBL27075730 | 0.76 | PLK1 (0.70) | AURKAAURKBSRCJAK2MAP3K5 | |
| SCHEMBL4218507 | 0.75 | AURKA (0.60) | AURKAAURKBSRCSCN9AJAK2 | |
| SCHEMBL3714522 | 0.75 | AURKA (0.66) | AURKAAURKBSRCJAK2MAP3K5 | |
| SCHEMBL2695389 | 0.75 | JAK3 (0.53) | SCN9AJAK2MAP3K5JAK3MAP4K4 | |
| SCHEMBL3723125 | 0.74 | AURKA (0.62) | AURKAAURKBSRCJAK2MAP3K5 | |
| SCHEMBL27075726 | 0.73 | NPC1 (0.67) | AURKAAURKBSRCJAK2SYK | |
| SCHEMBL27075735 | 0.72 | AURKA (0.66) | AURKAAURKBSRCSYKMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | claimed |