Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582912 | 0.81 | EGFR (0.56) | KDRKDM1ARCOR1FGFR3AURKA | |
| SCHEMBL374617 | 0.78 | EGFR (0.63) | KDRLCKKDM1ARCOR1FGFR3 | |
| SCHEMBL374856 | 0.75 | EGFR (0.57) | KDRLCKKDM1ARCOR1FGFR3 | |
| SCHEMBL378065 | 0.73 | KDR (0.53) | KDRFGFR3AURKACDK1PDGFRB | |
| SCHEMBL15127722 | 0.71 | FGFR3 (0.49) | KDRFGFR3AURKACDK1PDGFRB | |
| SCHEMBL374219 | 0.71 | KDR (0.62) | KDRLCKFGFR3AURKACDK1 | |
| SCHEMBL374119 | 0.69 | KDR (0.56) | KDRLCKFGFR3AURKACDK1 | |
| SCHEMBL27681379 | 0.68 | TUBB4A (0.53) | AURKASCN9ATUBB4ATUBBTUBA3C | |
| SCHEMBL374985 | 0.65 | FGFR3 (0.73) | KDRLCKCYP3A4FGFR3CYP2C19 | |
| SCHEMBL3253732 | 0.65 | KDM1A (0.58) | KDRKDM1ARCOR1AURKACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409969-A1 | Pyrimidine urea derivatives as kinase inhibitors | Novartis AG (CH) | 2012-01-25 | — | — | EP | disclosed |