Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026954 | 0.90 | MEN1 (0.46) | MEN1KMT2AALDH1A1PKMKDM4E | |
| SCHEMBL27861619 | 0.90 | MEN1 (0.46) | MEN1KMT2AALDH1A1PKMKDM4E | |
| SCHEMBL13259175 | 0.89 | MEN1 (0.42) | MEN1KMT2AALDH1A1PKMKDM4E | |
| SCHEMBL10907546 | 0.85 | MEN1 (0.46) | MEN1KMT2AALDH1A1PKMKDM4E | |
| SCHEMBL13259160 | 0.85 | MEN1 (0.39) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL28481211 | 0.84 | MEN1 (0.41) | MEN1KMT2AALDH1A1PKMKDM4E | |
| SCHEMBL5820577 | 0.84 | MEN1 (0.41) | MEN1KMT2AALDH1A1PKMKDM4E | |
| SCHEMBL13259358 | 0.83 | MEN1 (0.41) | MEN1KMT2AALDH1A1PKMKDM4E | |
| SCHEMBL17212019 | 0.83 | MEN1 (0.41) | MEN1KMT2AALDH1A1PKMKDM4E | |
| SCHEMBL13622353 | 0.83 | MEN1 (0.41) | MEN1KMT2AALDH1A1PKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006117800-A2 | NOVEL 3, 4-PROPYLENEDIOXYTHIOPHENE DERIVATIVES WITH PENDANT FUNCTIONAL GROUPS | INDIAN INSTITUTE OF TECHNOLOGY BOMBAY (IN) | 2006-11-09 | — | — | WO | claimed |
| US-20240190880-A1 | SMALL MOLECULE DEGRADERS OF ESTROGEN RECEPTOR WITH CEREBLON LIGANDS | REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-06-13 | — | — | US | disclosed |
| US-20240150360-A1 | Small Molecule Degraders of CBP/p300 Proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2024-05-09 | — | — | US | disclosed |
| US-20230357249-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS WITH A TRICYCLIC CEREBLON LIGAND | UNIV MICHIGAN REGENTS (US) | 2023-11-09 | — | — | US | disclosed |
| US-20230357249-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS WITH A TRICYCLIC CEREBLON LIGAND | UNIV MICHIGAN REGENTS (US) | 2023-11-09 | — | — | US | disclosed |
| US-20230357249-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS WITH A TRICYCLIC CEREBLON LIGAND | UNIV MICHIGAN REGENTS (US) | 2023-11-09 | — | — | US | disclosed |
| US-20220388978-A1 | CEREBLON E3 LIGASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-12-08 | — | — | US | disclosed |
| US-20220388978-A1 | CEREBLON E3 LIGASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-12-08 | — | — | US | disclosed |
| US-20220380368-A1 | SPIROCYCLIC ANDROGEN RECEPTOR PROTEIN DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN | 2022-12-01 | — | — | US | disclosed |
| WO-2022187417-A1 | SMALL MOLECULE DEGRADERS OF CBP/P300 PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-09-09 | — | — | WO | disclosed |
| US-20100029888-A1 | Click-Reaction Crosslinkable Multicomponent Silicone Compositions | WACKER CHEMIE AG (DE) | 2010-02-04 | — | — | US | disclosed |
| WO-2009135449-A1 | LIGANDS OF ESTROGEN RECEPTORS α AND β, METHOD OF THEIR PREPARATION AND PHARMACEUTICALS COMPRISING THEM | USTAV MOLEKULARNI GENETIKY AV CR, V.V.I. (CZ) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009135449-A1 | LIGANDS OF ESTROGEN RECEPTORS α AND β, METHOD OF THEIR PREPARATION AND PHARMACEUTICALS COMPRISING THEM | USTAV MOLEKULARNI GENETIKY AV CR, V.V.I. (CZ) | 2009-11-12 | — | — | WO | disclosed |
| CN-101412667-A | Preparation of 2-pimelie kelone compound | UNIV ZHEJIANG TECHNOLOGY (CN) | 2009-04-22 | — | — | CN | disclosed |
| CN-100448841-C | Process for preparing 2-cyclohexenone compounds | UNIV ZHEJIANG (CN) | 2009-01-07 | — | — | CN | disclosed |
| CN-101104587-A | 2-cyclohexenone compounds | UNIV ZHEJIANG (CN) | 2008-01-16 | — | — | CN | disclosed |
| CN-100358857-C | 2-cyclohexenone compounds and preparation method thereof | UNIV ZHEJIANG (CN) | 2008-01-02 | — | — | CN | disclosed |
| CN-1951903-A | Process for preparing 2-cyclohexenone compounds | UNIV ZHEJIANG (CN) | 2007-04-25 | — | — | CN | disclosed |
| WO-2006117800-A2 | NOVEL 3, 4-PROPYLENEDIOXYTHIOPHENE DERIVATIVES WITH PENDANT FUNCTIONAL GROUPS | INDIAN INSTITUTE OF TECHNOLOGY BOMBAY (IN) | 2006-11-09 | — | — | WO | disclosed |
| CN-1827577-A | 2-cyclohexenone compounds and preparation method thereof | UNIV ZHEJIANG (CN) | 2006-09-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357249-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS WITH A TRICYCLIC CEREBLON LIGAND | AR, GPER1, CRBN | MEN1 497/4885KMT2A 3389/4885ALDH1A1 291/4885 |
| US-20220380368-A1 | SPIROCYCLIC ANDROGEN RECEPTOR PROTEIN DEGRADERS | AR, NR5A1, ESRRA | MEN1 659/4885KMT2A 1043/4885ALDH1A1 132/4885 |
| US-20240150360-A1 | Small Molecule Degraders of CBP/p300 Proteins | EP300, CREBBP, NCOR1 | MEN1 1750/4885KMT2A 291/4885ALDH1A1 2142/4885 |
| US-20240190880-A1 | SMALL MOLECULE DEGRADERS OF ESTROGEN RECEPTOR WITH CEREBLON LIGANDS | ESR1, CRBN, ESR2 | MEN1 924/4885KMT2A 1525/4885ALDH1A1 1261/4885 |
| US-20220388978-A1 | CEREBLON E3 LIGASE INHIBITORS | CRBN, CUL3, UBE3A | MEN1 739/4885KMT2A 318/4885ALDH1A1 3487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.