Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | EPHB3 | P54753 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748363 | 1.00 | DRD4 (0.41) | DRD4DRD3DYRK1AMAP4K4JAK2 | |
| Hydrochloric Acid SCHEMBL3703425 | 0.98 | DRD4 (0.40) | DRD4DRD3DYRK1AMAP4K4JAK2 | |
| Hydrochloric Acid SCHEMBL3795000 | 0.98 | DRD4 (0.40) | DRD4DRD3DYRK1AMAP4K4JAK2 | |
| SCHEMBL6842161 | 0.85 | DRD4 (0.43) | DRD4DRD3DYRK1AMAP4K4JAK2 | |
| SCHEMBL6608758 | 0.84 | DRD4 (0.42) | DRD4DRD3DYRK1AMAP4K4JAK2 | |
| SCHEMBL23075880 | 0.82 | DRD4 (0.41) | DRD4DRD3DYRK1AMAP4K4JAK2 | |
| SCHEMBL22360676 | 0.82 | DRD4 (0.41) | DRD4DRD3DYRK1AMAP4K4JAK2 | |
| SCHEMBL22932522 | 0.79 | DRD4 (0.39) | DRD4DRD3DYRK1AMAP4K4JAK2 | |
| SCHEMBL19115073 | 0.79 | DRD3 (0.42) | DRD4DRD3DYRK1AMAP4K4EPHB3 | |
| SCHEMBL1290770 | 0.79 | DRD4 (0.39) | DRD4DRD3DYRK1AMAP4K4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136037-A1 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | claimed |
| WO-2010136037-A1 | NOVEL CALCIUM SENSING RECEPTOR MODULATING COMPOUNDS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2010-12-02 | — | — | WO | disclosed |