Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 5/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789593 | 0.80 | CA1 (0.60) | POLBKMT2AMEN1CA1CA2 | |
| SCHEMBL10121249 | 0.77 | TACR1 (0.43) | CTSDBACE1TACR1 | |
| SCHEMBL8116441 | 0.73 | CA1 (0.55) | POLBCA1CA2CA7CA9 | |
| SCHEMBL8116438 | 0.73 | CA1 (0.55) | POLBCA1CA2CA7CA9 | |
| SCHEMBL3805228 | 0.73 | PTGER3 (0.37) | TDP1KMT2AMEN1CTSDBACE1 | |
| SCHEMBL5987241 | 0.72 | CTSD (0.51) | TDP1CTSDBACE1CA1CA2 | |
| SCHEMBL10154614 | 0.72 | KDM4E (0.41) | TDP1CTSDBACE1CA1CA2 | |
| SCHEMBL14121701 | 0.72 | HRH3 (0.42) | TDP1KMT2AMEN1CTSDBACE1 | |
| SCHEMBL22785881 | 0.71 | TACR1 (0.48) | KMT2ACA1CA2CA7CA9 | |
| SCHEMBL16919633 | 0.69 | HDAC4 (0.41) | TDP1CTSDBACE1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |