Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 2/20 | 0.73 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.73 |
| ▸ | CDK9 | P50750 | 1/20 | 0.73 |
| ▸ | MST1R | Q04912 | 1/20 | 0.73 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.62 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 1/20 | 0.62 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.62 |
| ▸ | MARK3 | P27448 | 1/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.62 |
| ▸ | NEK4 | P51957 | 1/20 | 0.62 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.62 |
| ▸ | ITK | Q08881 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13077005 | 0.91 | CLK2 (0.61) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3796774 | 0.90 | CLK2 (0.60) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3801292 | 0.90 | KDM4E (0.69) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL13077188 | 0.88 | CLK2 (0.59) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3809483 | 0.86 | CLK2 (0.57) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3803908 | 0.83 | KDM4E (0.59) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3799820 | 0.82 | IRAK4 (0.67) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL13076229 | 0.81 | MAP3K7 (0.66) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3799346 | 0.81 | MEN1 (0.56) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3799856 | 0.81 | MEN1 (0.56) | CLK2CLK4CDK9MST1RIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |