Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 2/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.61 |
| ▸ | CDK9 | P50750 | 1/20 | 0.61 |
| ▸ | MST1R | Q04912 | 1/20 | 0.61 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796774 | 0.94 | CLK2 (0.60) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL13077188 | 0.91 | CLK2 (0.59) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3793594 | 0.91 | CLK2 (0.73) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3801292 | 0.88 | KDM4E (0.69) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3809483 | 0.87 | CLK2 (0.57) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3803908 | 0.82 | KDM4E (0.59) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3799820 | 0.81 | IRAK4 (0.67) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL13077039 | 0.80 | ITK (0.57) | ITK | |
| SCHEMBL13076229 | 0.80 | MAP3K7 (0.66) | CLK2CLK4CDK9MST1RIRAK4 | |
| SCHEMBL3799346 | 0.80 | MEN1 (0.56) | CLK2CLK4CDK9MST1RIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126922-A1 | BENZIMIDAZOLECARBOXAMIDES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-11-04 | — | — | WO | disclosed |