Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.63 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | INSR | P06213 | 12/20 | 0.56 |
| ▸ | IGF1R | P08069 | 12/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.55 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | CD74 | P04233 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3764374 | 0.81 | PDGFRB (0.75) | PDGFRBPDGFRAEGFRINSRIGF1R | |
| SCHEMBL24327435 | 0.81 | ALK (0.77) | PDGFRBPDGFRAEGFRINSRIGF1R | |
| SCHEMBL30378262 | 0.81 | ALK (0.77) | PDGFRBPDGFRAEGFRINSRIGF1R | |
| SCHEMBL26395575 | 0.78 | PDGFRB (1.00) | PDGFRBPDGFRAEGFRINSRIGF1R | |
| SCHEMBL29793855 | 0.78 | PDGFRB (1.00) | PDGFRBPDGFRAEGFRINSRIGF1R | |
| SCHEMBL30003588 | 0.77 | INSR (0.65) | PDGFRBPDGFRAEGFRINSRIGF1R | |
| SCHEMBL5282767 | 0.76 | ALK (0.56) | EGFRINSRIGF1RALKLRRK2 | |
| SCHEMBL18912630 | 0.76 | INSR (0.68) | PDGFRBPDGFRAEGFRINSRIGF1R | |
| SCHEMBL15244473 | 0.75 | INSR (0.68) | PDGFRBPDGFRAEGFRINSRIGF1R | |
| SCHEMBL26087590 | 0.75 | ALK (0.73) | PDGFRBPDGFRAEGFRINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138578-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | claimed |